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The post Scientists Discover New Pathway to Tan and Lighten Skin appeared first on Australian Science.
]]>Since doctors and health officials became aware of the dangers of UV rays on our skin, people have searched for a better alternative. Tanning beds and sun lamps have been linked to cancer, giving way to the evolution of spray tanning. Spray tanning formulas have even been enriched to contain organic oils and nourishing vitamins, in an attempt to make the option more appealing to customers.
However, new research from the Perelman School of Medicine at the University of Pennsylvania points to a new way to change the color of our skin. Researchers made an exciting discovery during a cancer study when they observed that sex hormones were affecting pigment production in regular cells. This breakthrough has uncovered a new doorway to controlling the lightening and tanning of the skin.
What Causes Skin to Change Color?
Scientists have long known the effects the sun has on skin. The sun darkens skin by causing damage to the DNA, which the body then repairs by increasing the production of melanocyte stimulating hormone (MSH). This short protein binds and activates another protein (MC1R) on melanocytes. Ultimately, these proteins trigger the production of pigment in skin cells.
An association was also previously made between sex hormones and pigment changes. The alterations in skin pigmentation in pregnant women suggested that sex hormones played a role. In fact, this transformation has been documented for more than 2,000 years, so it is not a new observation.
While this connection was previously known to exist, the exact mechanism and hormones were not yet known. Since many hormones and other molecules experience changes in levels during pregnancy, isolating which single or combination is responsible for the changes in skin pigmentation would prove a significant challenge.
The fact that taking birth control pills would sometimes cause women to develop a darker skin pigment on their face did provide further insight, as these only contain derivatives of the hormones estrogen and progesterone.
Discovering a New Door
During the study, Dr. Ridky and colleagues noticed that when adding estrogen levels typically seen during pregnancy to human melanocytes, they would respond by increasing the production of melanin. The content of melanin within the cells increased by 200%-300% after four days. They also discovered that the cells would produce less pigment when adding progesterone.
What the study revealed, was that estrogen was making pigment by accessing pathways that were already known to exist, it was just accessing them in a different manner. This new door, or receptor, was able to create the same outcomes. The issue then became trying to figure out what type of receptors these were, since melanocytes do not have the classic estrogen receptor, nor do they act on MC1R.
The scientists were able to identify the melanocytes express receptors accountable for the skin pigment effects following further testing. This occasion would be the first time that these receptors were studied. These were found to be two non-classical receptors; the GPER, a separate estrogen receptor, and PAQR7, a progesterone receptor.
The team was able to identify the receptors by developing synthetic progesterone and estrogen derivatives. These were designed only to fit those newly discovered receptors. The researchers selected synthetic hormones, as natural hormones could unintentionally attach to different receptors and set of unknown processes.
Researchers took further steps towards the development of a treatment drug, by incorporating the hormone derivatives into a gel. This formula was applied to mice’s ears and was found to increase melanin levels by roughly 60% within a three-week period.
The gel well also used on pigmented guinea pigs, of which one animal can display different skin colors. The animal had its haunches shaved on either side, with one part receiving the application of gel with the estrogen derivative, and the other a gel without derivatives or hormones. The side with the hormone derivatives was noticeably darker after a couple of weeks when compared to the other.
How These Results Could Lead to Treatments
The knowledge obtained during this study could help lead to a new form of therapeutics, which is of particular importance given the currently limited types of safe and effective treatment options available for those with pigmentation disorder. New therapies could offer help with melasma, post-inflammatory hyper and hypopigmentation, and maybe even vitiligo. Currently, correcting these disorders is difficult, without exposure to toxic bleaching agents or UV radiation.
The new information gathered during the study suggests that derivatives of these selective sex hormones can be used to affect the natural melanin production machinery. This discovery would allow for the opportunity to develop a drug that safely targets the natural pigment production pathway within a person’s skin cells.
Of course, an actual cream is still a long way from completion. The team would still need to create a formula that could be used by humans and ensure there were no side effects to using the cream. The compounds will also need to go through clinical trials and the FDA before they are made available to dermatologists. The development process itself is expensive, so a start-up has already been formed to attempt to woo potential investors.
The news would not only be significant for the medical industry but is also set to have a substantial impact on the cosmetics industry, where people already spend billions of dollars globally to change the color of their skin. Many of these attempts are unsuccessful, and even potentially dangerous, so developing a safe and effective alternative in the form of a drug could radicalise the industry.
As more and more people become aware of the cancer risks involved in UV tanning, whether you’re out in the sun or on the beds, they are turning to other options. Spray tanning is a far healthier option, with salons already offering several color levels lasting about a week at a time. However, the industry is constantly evolving, so this new potential option would offer customers an exciting alternative.
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The post How Modern Technology is Improving Health Care (Genome and Algorithms) appeared first on Australian Science.
]]>According to an article that rates this year’s medical advances according to their importance, at the top of the list is a new Ebola vaccine that is expected to be available later this year. Genome-based testing, which has the potential to increase the speed and flexibility of clinical trials for life-saving experimental treatments, ranked at number two.
Within the field of genome testing, one of the most important recent discoveries in medicine is CRISPR, which scientists have learned to use as a genome editing tool. CRISPR, an acronym for clustered regularly interspaced short palindromic repeats, is a natural defense mechanism found in bacteria. In the 1980s, scientists began observing patterns of bacterial genomes and now understand more about how the process of preventing viruses from replicating works.
A viral microbe copies the genetic material in each spacer into an RNA molecule. Cas9 enzymes cradle the RNA molecule, and in combination, they explore a cell. If they find genetic material that matches the CRISPR RNA, the viral RNA attaches to it. The Cas9 enzymes cut the DNA in half, preventing it from multiplying. Scientists believe that CRISPR has the potential to revolutionize biology because it can identify and remove bad genes from a DNA strand at very little economic cost.
Health Algorithms
According to a recent study, a new computer-based test can help predict the likelihood of developing dementia. The test utilizes a complex algorithm based on information such as a person’s age, weight, gender, social habits and previous medical history. Those whose test results showed them to be at higher risk could then take additional preventive measures by increasing activities that have been proven to improve memory. The focus of this technology is prevention.
Researchers used the test to assess the medical records of over 226,000 people over the age of 60. The algorithm proved to be so accurate that the developers decided to share it freely with other researchers. Their goal is that it become available to the public and an important element of a national healthcare database. They predict that it may take a few years to reach those goals.
Integrated Health Care Software
Another technological advance in medicine are software services that enable those in the medical profession to deliver a higher level of care. From a patient’s perspective, that higher level of care is manifested at every level of the health care system. Doctors are able to develop superior treatment plans by quickly and securely sharing medical information with specialists. All the time saved by not having to make physical appointments and drive to them can be used to increase communication between doctors and their patients. Automated scheduling capabilities also give other medical staff more time to communicate with the patient, which results in providing the doctor with more useful information.
One of the most common complaints of health care professionals in the last decade is the growing amount of paperwork they are required to complete. Health care professionals choose their careers based on a desire to spend their time having human interactions that result in people feeling better, not learning complex insurance billing procedures. Clinical trials have shown that one of the benefits for health care providers is the simplification and automation of some of the most time and energy consuming billing processes.
The Future
Scientists and health care professionals predict that the next thing that will revolutionize health care is the concept of precision medicine. Rather than offering every patient the same treatment for the same illness or condition, this concept focuses on developing individual treatment plans based on a number of genetic and environmental factors. Research in the field of epigenetics has demonstrated that genes are not, as was once believed, fixed, but are in fact affected by the environment.
The Precision Medicine Initiative, which is currently being developed and is expected to be launched later this year, promises to change the way medical professionals are trained by incorporating many of the newest scientific discoveries. This will allow doctors to more easily develop and implement valuable new techniques into their practices. Scientific advancements in genetics, computer technology, and medicine are making the future of health care look very bright indeed.
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The post Nanotechnology in Dentistry Creates Stronger Fillings appeared first on Australian Science.
]]>Dentists use dental composites to restore teeth to their original hardness and rigidity, making them essential in dental repairs such as restoration fillings. They are typically made of amalgams such as composites made of silica, plastic compounds or ceramic, or of mixtures of silver, mercury or tin.
The problem is that these can be prone to breakages and suffer from a short life span. In fact, it is thought that replacement fillings make up 75% of dentist’s work. The use of nanotechnology in dentistry has allowed engineers to come up with a viable solution to this problem.
Using Nanotechnology
The short lifespan of current dental composites have led engineers to look into the concept of using nanotechnology in dentistry, with fillings that could last longer than the conventional kind. The benefit of using nanomaterial is that when a material becomes smaller, it reduces the chance of it containing a defect, thus increasing the strength of that material.
The Development of NovaPro Flow
Hao Li, a professor at the University of Missouri’s college of engineering has developed a “flowable
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The post FDA Approved an Injection That Will Eliminate Your Double Chin appeared first on Australian Science.
]]>However, there is now a surgery-free way to remove the dreaded double chin thanks to a recently FDA-approved drug called Kybella (or deoxycholic acid). Approved as a treatment for adults with moderate-to-severe submental fat below the chin, Kybella is an injectable drug that works by helping the body absorb fatty tissue. In essence, the drug dissolves the submental fat under the chin by destroying the fat cell’s membrane, causing it to burst. The remains of the cell are then reabsorbed by the body’s normal metabolic pathways.
According to the results of numerous clinical trials, injecting Kybella into the affected area can produce a noticeable reduction in submental fat in just 6 months. Patients can receive up to 50 injections in a single treatment (which usually lasts around 5 minutes), and sessions must be spaced at least 1 month apart for best results. No bandages are required, and recovery time is between 2 and 3 days.
There are some side-effects, however, that patients need to be made aware of before embarking on this journey. The most common side-effects reported in clinical trials were swelling, bruising, pain, numbness, redness and areas of hardness around the treatment area. However, most of these should disappear within a few days after treatment.
It’s important to understand that Kybella can also cause far more serious side-effects, such as possible nerve damage in the jaw. Although these side-effects are much less common, some patients have reported uneven smiles, weak facial muscles, and even trouble swallowing after receiving treatment. Indeed, according to Amy G. Egan of the FDA’s Center for Drug Evaluation and Research, “Treatment with Kybella should only be provided by a licensed health care professional, and patients should fully understand the risks associated with use of the drug before considering treatment.
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The post Efficiency and Benefits of Massage Therapy appeared first on Australian Science.
]]>The advancements in medicine have provided numerous cures and treatments for diseases that were terminal just a hundred years ago. And while there is a pill that can solve many problems, there isn’t one that can give you what a simple old-fashioned massage can – a total relaxation. But, there is more to it.
Massage is so simple: it is natural, there are no chemicals involved and the person receiving the treatment needs to do absolutely nothing in order to feel the full effect. It has become a part of various aspects of everyday life, from free time to medicine, sports and even beauty treatments.
Illness is the most heeded of doctors:
to goodness and wisdom we only make promises;
pain we obey.
Marcel Proust
As one of the main alternative treatments, massage therapy is recommended and used for different problems, from coping with pain, cancer, fibromyalgia, HIV/AIDS and infant care to other conditions. Massage styles mostly performed today are Swedish, Deep tissue, Sports massage, Trigger point massage, Esalen, Pre-Natal, Acupressure, Shiatsu, Counterstrain, Ortho Bionomy, Reflexology and others.
Endocrine System. It is scientifically proven that massage regulates and stimulates hormone levels in the organism. Hormones such as serotonin, dopamine, epinephrine, oxytocin, cortisol and growth hormone are released into the organism during a massage session and they affect metabolism, mood, body temperature, the pituitary, thyroid, parathyroid, adrenal, pancreas, reproductive glands, as well as kidneys, liver, heart and gonads. For example, high cortisol levels, associated with depression, are reduced while serotonin levels increase. More than 12 studies, mentioned in the Journal of Clinical Psychiatry in 2010, indicate that massage reduces anxiety levels, as well as symptoms of depression, up to 50%.
Immune system. Massage enhances lymphocyte production, resulting in heightened immune response. Researchers in Cedars-Sinai’s Department of Psychiatry and Behavioral Neuroscience carried out a study with 29 participants. The results showed that a 45-minute session of deep-tissue Swedish massage decreases cortisol levels, while it increases white blood cells.
Muscles. Another research, published in “Science Translational Medicine
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The post Common Myths and Truths About Food appeared first on Australian Science.
]]>It all comes down to due diligence. When you hear the latest claim, check out the scientific basis of the study and who was behind it. If McDonald’s comes out with a study that proves eating burgers all day is good for you, you may want to approach with a little caution.
The following claims are some of the most common, with some having just hit the scene while others have been around for what seems like centuries. Each can either be debunked or proven with just a little bit of research – check out the results below.
This is probably one of the most widely believed myths out there. It’s rare to find a child who wasn’t encouraged to eat their carrots while at the dinner table, with improved vision as the promise. Sadly, the dream of developing x-ray vision just like Superman simply never came true.
It’s easy to see why this myth has endured. Carrots are packed with beta carotene (aka Vitamin A), which is known to improve overall eye health. However, having healthy eyes doesn’t translate to 20/20 vision.
Carrots will improve your vision if you’re highly deficient of Vitamin A. And carrots aren’t the only vegetable that can help you boost your intake – broccoli, pumpkin, and most leafy greens can do the job equally well.
Dieters these days are so obsessed with numbers that they don’t look at ingredients. This has unfairly lumped peanut butters in the ‘it makes you fat’ camp. While it’s true that peanut butter contains fat, it’s also the case that it comes packed with the good kind of fat. Monounsaturated fat will actually help keep your heart healthy, as illustrated by Harvard Medical School.
Not only that, peanut butter also delivers a range of other benefits. For instance, you can protect yourself from developing benign breast disease. You’re also less likely to develop type-2 diabetes. Just make sure you get the good kind– avoid added fat or sugar if you can.
Aspartame and other artificial sweeteners are found in most diet drinks – it’s likely that if you don’t for the full-sugar version, you’re ingesting a hefty dosage of aspartame instead. The debate on whether it causes healthy problems is one of the most controversial.
The fact is that there is no conclusive evidence. Most studies conducted thus far have not shown any links between cancer and the artificial sweetener. Studies that purportedly do establish causation simply do not have a large enough data set or have other inconsistencies.
So should we discard the warnings and continue drinking diet sodas? We wouldn’t advise it, especially if you’re consuming soft drinks in large quantities – overdoing anything is never a good thing.
Can fish really boost your brainpower? Yes, This is particularly applicable in those of us who are getting a bit long in the tooth. This study from Chicago’s Rush University Medical Center highlights the abundance of links between cognitive performance and the regular consumption of fish, including a 60% risk reduction of developing Alzheimer’s disease.
So if you’re suspecting your brain of feeling the knocks of old age, try and add fish to your diet. Once a week is enough to make a difference. Considering the overall benefits of fish anyway, there’s no reason not to include it in your menu.
Before you take our claims and run with them, do your own research and verify the studies yourself. It’s all about knowing what you’re adding to your diet and being aware of the benefits and downsides of a particular food item. Don’t believe hype or unfounded claims – always look for the numbers and the scientific proof before buying into the next fad.
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The post Changing Time Zones: The Health Effects of Jet Lag appeared first on Australian Science.
]]>Besides the lack of hydration, uncomfortable seating position and questionable food we are subjected to during an economy flight, the main reason why jetlag catches up on us is to do with our circadian rhythm being desynchronised. Until we evolve to adapt to frequent travel between time zones, this cannot be ignored.
A lot of our body’s physiology is regulated by neurotransmitters that can be classified as amino acids, peptides and monoamines. One example of a monoamine is melatonin, which is affected by sunlight over a 24-hour period (circadian rhythm). A disruption in this circadian rhythm can profoundly affect body temperature, digestion, heart rate, blood pressure, hormones and state of mind (source –The State Government of Victoria).
Naturally corresponding with the amount of hours in the day, there 24 time zones around the world. It has been documented that travelling over two time zones will have a marginal effect to a person’s circadian rhtyhm but travelling over any more than three can cause desynchronisation to a substantial degree (source – Reilly T).
The Effects
Travelling west will also make jetlag easier to recover from due to the circadian rhythm being temporarily prolonged to about 27 hours, making it easier for the body to adapt (Reilly T). When experiencing a shift of any more than 12 time zones however, travelling east or west does not make a difference. That would be the equivalent of flying from Adelaide to Sao Paulo, Brazil. It would be hard not to pull up a bit rough after a marathon flight such as that.
After travelling east, it is also common for people to have trouble getting out of bed at a normal time in the morning while flying back from the west will result in waking up before dawn (Libassi L, Emad YA).
Suffering from jet lag may be inconvenient for someone coming back from a holiday or the occasional business trip but it can have further implications for those travelling more regularly as a part of their day-to-day lifestyle.
According to Centers for Disease Control and Prevention (CDCP), the amount of days jet lag could last for can be calculated.
In the United States, where sporting teams could experience up to four different time zone changes on a flight to an away game, the overall effect of disrupted circadian rhythms to the whole team can impact results and change the course of a season.
A three-year study on 19 North American Major League Baseball (MLB) teams found the home team could expect to score 1.24 more rune than usual when the visitor had just completed eastward travel. Home teams also scored 0.62 more runs during the day than the night (source – Recht LD, Lew RA, Schwartz WJ).
A more recent 10-year study found MLB teams that travelled through three time zones have as much as a 60% chance of losing their first game upon arrival (Winter WC, Hammond WR, Green NH, Zhang Z, Bliwise DL).
Jet lag can no doubt take its toll for sporting teams and businessmen who must travel as part of their job but there usually is a period of rest for the body to recover from crossing multiple time zones. Cabin crew members on international flights regularly do this more than anyone with as little as two days break before their next flight.
A study on 62 experienced female cabin crew members found increased secretion of the stress hormone, cortisol, and impaired nonverbal cognitive processing for cabin crew members who travelled on more transmeridian flights with less days off. The results showed the body could not even adapt to the stress of jet lag with some participants having as much as four years experience in the field (Cho K, Ennaceur A, Cole JC, Suh CK).
Another study on 45 female flight attendants and 26 teachers confirmed the variability in melatonin production as high as 25% was twice as likely to be associated with flight attendants (Blosser F).
The Treatment
As mentioned previously, melatonin is a key factor for regulating sleep. It also promotes the release of antioxidant enzymes and can act as a defense against free radicals (Rodriguez C, Mayo JC, Sainz RM, Antolín I, Herrera F, Martín V, Reiter RJ).
Available as a 2mg prescription tablet in Australia, melatonin can help combat jet lag easily and with minimal side-effects. Although, the Therapeutic Goods Administration does not advise taking melatonin in combination with alcohol, Thioridazine and Imipramine, and benzodiazepine or other hypnotics.
Nine out of ten randomised trials on airline passengers, airline staff and military personnel crossing five or more time zones saw decreased jet lag symptoms in subjects when melatonin was taken one hour before the destination bedtime (10pm to midnight). Doses of melatonin closer to 5mg were seen to be significantly more effective than a slow-release 2mg dose (Herxheimer A, Petrie KJ).
Adjusting to a new time zone before arrival, known as preentrainment, can be another way of dealing with jet lag. This is to do with our chronosense, a biological response to light generated by the suprachiasmatic nucleus that can be active even in blind newborn babies (Sernagor E).
A study on 28 participants trialled a three-day treatment of exposing differing amounts of light in the first 3.5 hours of waking, advancing normal wake time by one hour each day. Participants who received the greatest amount of bright light over the three days experienced a phase shift of nearly two hours, which can be particularly helpful for those travelling east and arriving in the morning (Burgess HJ, Crowley SJ, Gazda CJ, Fogg LF, Eastman CI)
The disadvantage of this treatment is the inconvenience of being exposed to bright light and still carrying out normal morning duties.
Another study from the same research team combined morning bright light exposure with afternoon doses of melatonin over three days before a flight. Participants experienced a phase advancement of nearly 2.5 hours and no jet lag symptoms with a 0.5mg dose of melatonin and alternating exposure of bright and dim light for 30 minutes (Revell VL, Eastman CI).
Previously, the typical method of dealing with jet lag would be drinking yourself to sleep on the flight followed by a stupendous amount of coffee consumed on arrival. The health implications of these methods are obviously detrimental. Until we make genetic advances to cope with jet lag however, the other options available today are safe and effective for returning back to your regular time zone.
Images courtesy of visual.dichotomy, Will Fisher and Wikimedia.
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The post Alternative therapies – the facts appeared first on Australian Science.
]]>Many people will only use alternative therapies whereas others believe in a complementary approach, whereby elements of conventional and alternative therapies are used to get the desired result.
Are alternative therapies a safe and effective choice? Here are the facts.
Types of alternative therapies
There are dozens of types of alternative therapies, which range from practitioner-based to therapies that can be completed in the home. Many of these therapies are closely aligned with each other, whereas others have very different thoughts and methods of diagnosis and treatment.
Some of the more common types of therapies used in the developed world, as listed by the National Centre for Complementary and Alternative Medicines, include acupuncture, hypnosis, diet-based therapies (e.g. Atkins diet, South Beach diet), massage, meditation, naturopathy, yoga, chiropractic and energy healing therapy.
Alternative therapies today
In an American study, the 2007 National Health Interview Survey, it was found that 38 per cent of adults and 12 per cent of children had used some form of complementary or alternative therapy in the 12 months prior to the survey.
Additionally, the survey found that Americans had spent $33.9 billion on alternative therapy services and products. As an increasing amount of funding is put into researching the benefits of alternative therapies, more people, including medical doctors, are taking it seriously.
As an example of the effects that research can have on the uptake of an alternative medicine in the general public, in 2002 the most commonly used natural product was echinacea. By 2007, echinacea had dropped to third place and omega 3 fish oil use had drastically increased. This came after several positive studies proved the benefits of fish oil and the mainstream media jumped on it (NCCAM, 2008).
What can alternative therapies help with
Alternative therapies can offer relief from a wide range of health problems, and can also assist in the prevention of illness. While many of the types of alternative therapies can offer a very broad spectrum of health benefits (e.g. naturopathy), others are much more specific (e.g. chiropractic for spine-related pain relief)
The most commonly used alternative therapies are used to treat back and neck pain, largely through the use of a chiropractor. Arthritis, anxiety, insomnia and head or chest colds are also on the list of commonly treated illnesses. (NCCAM, 2008).
Scientific evidence
The main problem that has always inhibited the large-scale uptake of alternative therapies is the lack and quality of scientific evidence. Instead, a lot of the claims made by providers of services and products are anecdotal.
The popularity of alternative therapies in recent years has demanded for a more serious, scientific look into their benefits. In a positive move for the industry, the National Centre for Contemporary and Alternative Medicines (NCCAM) was established in 1999 to help fund detailed scientific-based research into the safety and efficacy of alternative and complementary therapies.
Since then, a range of therapies have been endorsed and scientifically proven. For example, several studies into the benefits of chiropractic therapy found that spinal manipulation could provide mild-to-moderate relief from low-back pain and was proven to be as effective as conventional medical treatments (Rubinstein et al, 2011).
Additionally, women are turning to acupuncture as a fertility and miscarriage prevention treatment, even more so now after scientific evidence has proven it helpful. Manheimer et al (2008) found that women who are using IVF treatment could benefit from the use of specialist fertility acupuncture.
5 Quick facts about alternative therapies
Additional Sources:
http://www.sciencebasedmedicine.org/the-facts-of-the-alternative-medicine-industry/
http://report.nih.gov/nihfactsheets/ViewFactSheet.aspx?csid=85
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